Advancing autoimmune research through integrated discovery
A new model for autoimmunity
Autoimmune research has long been fragmented across institutions, disciplines, and disease areas. The Colton Consortium was built to change that.
- Exclusive focus on autoimmune diseases — Every initiative, every dollar, and every collaboration is directed toward advancing autoimmune science.
- World-class expertise unified across institutions — Leading investigators across five premier institutions, creating research capacity no single lab can match.
- Integrated discovery by design — Shared vision and coordinated strategy mean findings move across research areas rather than staying siloed.
Shared goals, collective insights
Collaboration within the Colton Consortium isn't incidental — it's structural — creating the conditions for discovery at scale.
- Building toward shared platforms — Developing the infrastructure to generate cross-disease insights across the Consortium.
- Ongoing coordination across Colton Centers — Investigators share data, methodologies, and emerging insights across partner institutions in real time.
- Funding aligned to shared priorities — Resources flow toward the research questions that matter most to the Consortium's scientific mission, not competing institutional agendas.
From foundational discovery to real-world impact — explore the Colton Consortium's work.
News & Events
What a "Silenced" Chromosome Can Tell Us About Autoimmunity
Penn Colton Center researcher Montserrat Anguera reveals how B cells maintain X chromosome inactivation, and how its breakdown drives lupus, offering new insight into female-biased autoimmune disease and treatment targets.
Yale Receives $2.5M Gift to Advance Autoimmune Research
A $2.5 million gift from the Colton Foundation will advance autoimmune research at Yale School of Medicine and strengthen collaboration across the Colton Consortium for Autoimmunity's four member institutions.
Colton Consortium for Autoimmunity Announces $15 Million Investment
Penn Medicine has opened a new research facility housing the Colton Center for Autoimmunity alongside immune health, vaccinology, and infectious disease teams — designed to accelerate breakthrough science through collaboration.
Science that moves the field forward
The Colton Consortium measures progress by scientific rigor and reach, and the strength of the network driving these advancements.
- Mechanistic insights that inform future interventions — Colton research deepens understanding of how autoimmune diseases develop, persist, and differ — knowledge that underpins the next generation of diagnostics and therapies.
- Scientific leverage through collaboration — The Consortium model means findings compound across teams, disciplines, and disease contexts rather than staying within isolated labs.