My overall research goal is to elucidate the epigenetic and transcriptional networks that control CD8 T cell differentiation, including T cell exhaustion in cancer and chronic infection. These studies combine mouse models of T cell differentiation and human immunology with next-generation sequencing, single cell genomics, high dimensional cytometry, CRISPR technologies, and computational analysis.I graduated from Mount Holyoke College summa cum laude in 2007, then earned a PhD from Yale University. My graduate work in the laboratory of Mark J. Shlomchik investigated T cell - B cell interaction in systemic autoimmune disease and resulted in a novel method for identifying and studying autoreactive T cells. As a postdoctoral fellow in E. John Wherry’s lab, I was awarded a Cancer Research Institute-Mark Foundation Fellow and studied the epigenetic state of CD8 T cells after immune checkpoint blockade in melanoma patients.
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